Published: 25 July, 2017 | Volume 1 - Issue 1 | Pages: 026-038
Possible mechanisms responsible for protein aggregate formation catalyzed by TGs. Transglutaminase activity could produce insoluble aggregates both by the formation of Nε-(γ-L-glutamyl)-L-lysine (GGEL) isopeptide bonds (left side of the figure) and by the formation of N,N-bis-(γ-L-glutamyl)polyamine bridges (right side of the figure) in the mutated huntingtin.
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