Research Article

Similarity between Some Biological Systems, Organotropism and Metastatic Process: Active Role Played By Secondary Organ?

Luisetto M*, Behzad Nili-Ahmadabadi, Hossein Nili-Ahmadabadi, Ghulam Rasool Mashori, Gamal Abdul Hamid, Kausar Rehman Khan, Behrooz Nili-Ahmadabadi, Ahmed Yesvi Rafa and Luca Cabianca

Published: 19 June, 2018 | Volume 2 - Issue 1 | Pages: 019-051

According to literature, about 90% of death from cancer is related to metastasis. Metastatic process present many similarity to some other biological processes. Once we have examined some relevant biomedical literature, by understanding the real causes of metastasis, it would become much more possible to introduce new therapeutic strategies to delay or in some cases even to stop this kind of killer process. Breast cancer, as an example, produces metastasis to different organs, which seems to be related to the subtype. We believe that a deep understanding of the roles of breast cancer cells and their interactions with the liver microenvironment in early breast cancer metastasis could be a crucial factor for the design and development of effective BCLM breast cancer liver metastases therapeutic strategies and to better understand the general process. Let’s suppose the secondary organ or organs can be considered as incubator/s for the primary metastatic cells. What kind of consequences we can have in therapy field if there is an active regulating role in determining the location of secondary cancers?

Let’s observe the role played by liver, bone marrow, CNS central nervous system, lungs, lymphocytes and other secondary locations/organs a little bit closer or maybe from a different angle let’s suppose we try to come up with just a hypothesis. Just let’s take this as a possibility, and we take the thread to see where it takes us.

Read Full Article HTML DOI: 10.29328/journal.ibm.1001012 Cite this Article Read Full Article PDF


Organotropism; Liver metastasis; Cancer; Pathology, Immune systems; New therapeutic strategies; Biology; Botany; Cancer; Metastasis; Organ specific metastasis; Metastatic colonization


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