Abstract

Short Communication

Erectile Dysfunction and Coronary Artery Disease: Two manifestations, one same underlying mechanism

Jonathan Cardona-Vélez* and Laura Ceballos-Naranjo

Published: 12 January, 2018 | Volume 2 - Issue 1 | Pages: 003-006

Erectile dysfunction (ED) is a common disorder whose prevalence increases with age. Over time a strong correlation between erectile dysfunction and cardiovascular disease has been established as the result of the same pathophysiological process: endothelial dysfunction and atherosclerosis. Because small vessels of the penis can be affected by atherosclerotic plaque earlier than coronary arteries, carotids or femoral arteries, men often have symptoms of ED long before the signs of cardiovascular disease appear. For this reason, ED can act as a marker of early atherosclerosis that predicts the onset of cardiovascular disease at a later time.

Read Full Article HTML DOI: 10.29328/journal.ibm.1001010 Cite this Article Read Full Article PDF

Keywords:

Erectile dysfunction; Coronary artery disease; Cardiovascular disease; Endothelial dysfunction; Atherosclerosis

References

  1. Canat L, Canat M, Guner B, Gurbuz C, Caşkurlu T. Association between renal function, erectile function and coronary artery disease: detection with coronary angiography. Korean J Urol. 2015; 56: 76-81. Ref.: https://goo.gl/cDh9rR
  2. Menezes A, Artham S, Lavie CJ, Milani RV, O'Keefe J. Erectile dysfunction and cardiovascular disease. Postgrad Med. 2011; 123: 7-16. Ref.: https://goo.gl/EKyrVq
  3. Gandaglia G, Briganti A, Jackson G, Kloner RA, Montorsi F, et al. A Systematic Review of the Association between Erectile Dysfunction and Cardiovascular Disease. European Urology. 2014; 65: 968-978. Ref.: https://goo.gl/AUEj3f
  4. Demirkol S, Balta S, Kucuk U, Celik T, Arslan Z, et al. Association between microvascular angina and erectile dsyfunction. Int J Impot Res. 2014; 26: 124-127. Ref.: https://goo.gl/hNPHXP
  5. Sanchez E, Pastuszak AW, Khera M. Erectile dysfunction, metabolic syndrome, and cardiovascular risks: facts and controversies. Transl Androl Urol. 2017; 6: 28-36. Ref.: https://goo.gl/u9JX3Y
  6. Raheem OA, Su JJ, Wilson JR, Hsieh TC. The Association of Erectile Dysfunction and Cardiovascular Disease: A Systematic Critical Review. Am J Mens Health. 2017; 11: 552-563. Ref.: https://goo.gl/DfAPng
  7. Katsiki N, Wierzbicki AS, Mikhailidis DP. Erectile dysfunction and coronary heart disease. Curr Opin Cardiol. 2015; 30: 416-421. Ref.: https://goo.gl/xsyUgm
  8. Braffett BH, Wessells H, Sarma AV. Urogenital Autonomic Dysfunction in Diabetes. Curr Diab Rep. 2016; 16: 119. Ref.: https://goo.gl/SbkKxZ
  9. Brock G. Diagnosing erectile dysfunction could save your patient’s life. Can Urol Assoc J. 2014; 8: 151-152. Ref.: https://goo.gl/CYSD8x
  10. Tian GX, Liu XP, Zeng XT, Su XJ, Wei WL, et al. Bibliometric analysis on relations between cardiovascular disease and erectile dysfunction. Zhonghua Liu Xing Bing Xue Za Zhi. 2017; 38: 810-813. Ref.: https://goo.gl/B6kFd7
  11. Hackett G. The Graham Jackson Memorial Lecture ISSM 2016-"The Man Who Knew Too Much": Time to Recognize Erectile Dysfunction and Low Testosterone as Independent Risk Factors for Cardiovascular Disease. Sex Med Rev. 2017; 5: 256-265. Ref.: https://goo.gl/u8ByZp
  12. Canat L, Cicek G, Atis G, Gurbuz C, Caskurlu T. Is there a relationship between severity of coronary artery disease and severity of erectile dysfunction? Int Braz J Urol. 2013; 39: 465-473. Ref.: https://goo.gl/8tT1R5
  13. Lerman A, Zeiher AM. Endothelial function: cardiac events. Circulation. 2005; 111: 363-368. Ref.: https://goo.gl/FKAj4P
  14. Montorsi P, Ravagnani PM, Galli S, Rotatori F, Veglia F, et al. Association between erectile dysfunction and coronary artery disease. Role of coronary clinical presentation and extent of coronary vessels involvement: the COBRA trial. Eur Heart J. 2006; 27: 2632-2639. Ref.: https://goo.gl/SXrCkk
  15. Kumar J, Bhatia T, Kapoor A, Ranjan P, Srivastava A, et a. Erectile dysfunction precedes and is associated with severity of coronary artery disease among Asian Indians. J Sex Med. 2013; 10: 1372-1379. Ref.: https://goo.gl/ximYXk
  16. Osondu CU, Vo B, Oni ET, Blaha MJ, Veledar E, et al. The relationship of erectile dysfunction and subclinical cardiovascular disease: A systematic review and meta-analysis. Vasc Med. 2017. Ref.: https://goo.gl/FbXggL
  17. Nehra A, Jackson G, Miner M, Billups KL, Burnett AL, et al. The Princeton III Consensus recommendations for the management of erectile dysfunction and cardiovascular disease. Mayo Clin Proc. 2012; 87: 766-778. Ref.: https://goo.gl/dMrK7V
  18. Pastuszak AW, Hyman DA, Yadav N, Godoy G, Lipshultz LI, et al. Erectile dysfunction as a marker for cardiovascular disease diagnosis and intervention: cost analysis. J Sex Med. 2015; 12: 975-984. Ref.: https://goo.gl/pFKUtX

Similar Articles

Recently Viewed

Read More

Most Viewed

Read More

Help ?